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Lignans from flaxseed, converted to enterolactone (EL) and enterodiol by gut microflora within the intestines, possess weak estrogenic activity that competes with endogenous oestrogens for ER binding causing decreased mitogenic stimulation and lower circulating estrogen concentrations via upregulation of sex hormonebinding globulin (SHBG) (189, 190)
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[DOI] [PubMed] [Google Scholar] 46.Wang Y., Liu L., Le Z., Tay A
Leucovorin appears to offer a way around that metabolic roadblock
