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However, the largest Phase IIb trial involving 536 participants failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading to development termination in 2007
Impact on Net Weight: The TFA salt contributes to the total mass of the product
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Animal reproduction studies with semaglutide have shown embryofetal toxicity, including structural abnormalities, at exposures below those expected at therapeutic doses in humans
