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394,395 As mentioned above, HSF1 is subject to numerous PTMs that govern its activation or inhibition at different levels, and the mediators of these PTMs themselves, or their upstream receptors or sensors, help integrate multiple different stimuli in the HSF1-mediated response
It is performed entirely with the hands, without the use of oils or creams
After IV injection, the onset of analgesia occurs in about 30 minutes, with a peak effect around 1 to 2 hours, and a duration of action of 4 to 6 hours
