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de Lima M, Couriel D, Munsell M, Westmoreland M, Shah H, deJesus J, Hosing C, Ghosh S, Anderlini P, Gajewski J, Andersson B, Kornblau S, Hocking B, Ippoliti C, Giralt S, Shpall E, Champlin R

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349 If the ulcers fail to show a 50% reduction after 4 weeks of appropriate management via conventional methods, several advanced therapies, including negative-pressure therapy, growth factor therapy, bioengineered tissue, acellular matrix tissue, stem cell therapy, hyperbaric oxygen therapy, and, most recently, topical oxygen therapy, can be considered

[40][41] This is due to the reliance on endogenous receptors controlling hormone secreting glands and tissues