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Description
This study received approval from the SingHealth Centralized Institutional Review Board (CIRB Ref: 202008-00040), and all participants provided written informed consent

Excessive amounts of APAP metabolism in the liver generate a toxic intermediate, N-acetyl-p-benzoquinone imine (NAPQI), mainly through the activity of cytochrome P450 enzymes CYP2E1 and CYP1A2
[DOI] [PubMed] [Google Scholar] 35.Montgomery SM, Lambe M, Olsson T, et al

Clinics that offer this service, like Halo Health in Solihull, are required to have trained medical staff to manage the infusion rate and screen for any health contraindications