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Similarly, sildenafil reduces oxidative stress in the smooth muscle of rabbit penile blood vessels exposed to substances which induce ROS production such as TNF-, nicotine, homocysteinecopper combination, and the thromboxane A2 mimic [146,199,200]

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However, when the experimental conditions are designed to reflect patients with severe liver injury, lack of regeneration, and acute liver failure, a dose of 600 mg/kg APAP must be used [121]

This is true with respect to THC, but only with certain doses (Sarne, 2019)