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A Multicentre, Randomised, Double-Blind, Placebo Controlled, Phase II Study to Evaluate the Safety and Efficacy of Subcutaneous Bioresorbable Implants of Afamelanotide (CUV1647) for the Prophylactic Treatment of Pre-Cancerous Skin Lesions of the Head, Forearms and Hands in Immune Compromised, Organ Transplant Patients (Report)
This special characteristic is frequently referred as complex I syndrome, with the symptoms of reduced mitochondrial respiration with malate-glutamate and ADP and of reduced complex I activity

Xia W, et al