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[DOI] [PMC free article] [PubMed] [Google Scholar] 102.Wang, C.-L

They engage and activate macrophage TLR4/TLR family receptors, inducing IKK-NF-B axis phosphorylation, upregulating CD80/CD86 co-stimulatory molecules, and significantly boosting phagocytic capacity and the expression of key inflammatory mediators, including NO, TNF-, IL-1, IL-6, and iNOS

Update on tocilizumab in rheumatoid arthritis: a narrative review

Xie Y, Zhang D, Zhang J, Yuan J