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The mitochondrial metabolism inhibitor CPI-613 in combination with high-dose Ara-C and mitoxantrone is highly active in poor-risk relapsed or refractory acute myeloid leukemia

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Additionally, the amenability of PLGA nanosystems to functionalization by ligands (lactoferrin) or polymers (PEG) could facilitate targeted delivery, ensuring efficient delivery of their cargos to target tissues and thus minimizing off-target effects 31
