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Description
In this study, the authors identify a first histone acetyltransferase, known as Gcn5 in yeast, revealing a potential role of histone modification in regulating gene expression

In people with good health, the liver and kidneys produce and store enough of the compound to prevent deficiency

In line with the potential of ABC transporters to efflux anticancer agents, their overexpression has been associated with poor response to chemotherapy and multidrug resistance (MDR) 27

Second, they harbor enzymes negatively regulating T effector cell functions, such as nitric oxide synthase (NOS) and Indoleamine 2,3-Dioxygenase (IDO) (Munn et al., 2005
