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Intriguingly, despite robust inflammatory activation, they reported no changes in the expression of canonical tight junction proteins (e.g., Cldn5), adherens junction molecules (e.g., Cdh1), or components of the basal lamina across both early and late phases of the disease model
doi: 10.1073/pnas.93.20.11213
Executive Guidance: Protecting Clinical Integrity The transition of BPC-157 to Category 2 represents a clear enforcement priority regarding synthetic peptides
Novo submitted the drug to the US FDA in December 2025 based on the REDEFINE-1 and REDEFINE-2 trials
