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Elevated intracellular Ca 2+ levels trigger downstream neurotoxic cascades, including activation of proteases (e.g., calpains), generation of reactive oxygen species (ROS), mitochondrial dysfunction, and initiation of apoptotic pathways [66]
They do not measure the strength of the clinical effect
For Opioid Use Disorder (OUD) , several medications are considered the gold standard, each with unique benefits and limitations
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