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Clinical trials on DSIP have produced mixed results

Iodothyronines are also metabolized by glucuronidation, although this appears more important in rodents than in humans (183)

doi: 10.3389/fpsyt.2021.638981 67 UrsiniF.MaiorinoM

Phenformin was well tolerated up to high concentrations, which agrees with its previous use as an antidiabetic drug before it was withdrawn from the market in the 1970s due to more frequent fatal cases of lactic acidosis compared to the alternative antidiabetic metformin