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Failure to account for environmental exposures may explain the lack of consistency

Methylfolate Although both folinic acid and methylfolate are forms of active folate, they serve distinct biological purposes: Folinic acid (leucovorin) primarily supports the synthesis of DNA, RNA, histones, GTP, nitric oxide (NO), and tetrahydrobiopterin (BH4)key molecules in cellular growth and neurotransmitter production

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doi: 10.1146/annurev.bi.63.070194.000325