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Thus, in bioprocesses such as the transformation of trimethylammonium compounds, in which substrate and product transport and activation are associated to energy and the performance of the bioprocess involves the mobilization of cellular cofactors, strain improvement by metabolic engineering is also a strategy of prime importance, since new cell catalysts can be purposely devised [26, 72]

For example, memantine a non-toxic, non-phychotomimetic, NMDA receptor antagonist, is neuroprotective and has been used as a treatment for Alzheimer's and Parkinson's disease (Kornhuber 1994