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10.1007/978-1-4614-6093-6029 Adv

Mendelian randomization is a technique that uses genetic variants as instrumental variables to assess the causal relationship between an exposure (in this case, blood Pb levels) and an outcome (cardiovascular disease, hypertension, blood pressure, and diabetes)

Furthermore, specific molecular mechanisms by which diabetes disrupts spermatogenesisparticularly in areas such as epigenetic regulation, mitochondrial dysfunction, and ER stressremain inadequately explored

Every-other-day or less-frequent dosing has been explored in some studies but requires higher per-dose amounts to compensate