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Whole-body deficiency of MLKL [65], NLRP3 [67, 162], or CyPD [163] also prevented obesity-induced, or high-fat diet (HFD)-induced insulin resistance and glucose intolerance
Results of a previous study demonstrated that uridine-cytidine kinase-like 1 (UCKL1) enhances the proliferation and metastasis of CRC cells via the UCKL1/Nrf2/SLC7A11 axis, ultimately inhibiting ferroptosis and promoting CRC development and progression (84)
Du Y, Zhao HC, Zhu HC, Jin Y, Wang L
ROS also impair proteasome and mitochondrial function
