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It promotes neurogenesis and enhances the action of neurotrophic factors. An ongoing clinical trial (NCT03641404) testing ergothioneine supplementation (25 mg three times weekly) in elderly individuals with mild cognitive impairment shows promising preliminary results: Significant increases in blood ergothioneine levels Improvements in global cognitive performance scores Trending improvements across multiple cognitive assessments Reduction in neurofilament light protein (a marker of neuronal injury) Recent 2025 research revealed that ergothioneine significantly increases brain-derived neurotrophic factor (BDNF) expression in nerve cells [8]

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Biomarker case-detection and prediction with potential for functional psychosis screening: development and validation of a model elated to biochemistry, sensory neural timing and end organ performance

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