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Because of this dual role, MOTS-c is often described as a mitokine a mitochondrial-derived signaling molecule that influences cells throughout the body

Among the selected pac-lipids, the NTD interacted mainly with cholesterol and sphingosine (Fig 5), in accordance with previous results in the mammalian NPC system (56), whereas NPC2 crosslinked with similar intensity with all tested ligands (Fig S4), suggesting a broader lipid binding function

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