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Methylglyoxal-induced functionality loss of mural cells Mural cells of the brain microvasculature refer to the pericytes and VSMCs, which surround the BMECs [10]

In addition, macrophages are capable of producing a variety of inflammatory factors, such as NF-B, TNF-, IL-2, IL-6 and IL-8 and activating nuclear transcription factors like NF-B, which also play an important role in the progression of MASLD (92)

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This response is largely attributed to its influence on key signaling pathways, namely the MAPK and NF-B pathways, which reduce the expression of pro-inflammatory cytokines such as IL-6, IL-1, and TNF- [57]