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2.1.1 Senescence-associated secretory phenotypeSASP The senescence-associated secretory phenotype, also known as the senescence-messaging secretome, functions as a collection of proteins released by senescence cells into their microenvironment, serving as a key marker of cellular aging [32, 33]

Myofibroblasts also exhibit altered mechanosensing, a process that is often dysregulated in chronic fibrotic conditions but is less active or more tightly controlled in quiescent fibroblasts [169]

Inflammatory reactions in the liver may be accompanied by oval cell and fibroblast proliferation and the propensity for hepatocellular proliferative responses to replace lost parenchyma

In the context of Long COVID, where chronic neuroinflammation is a primary driver of cognitive dysfunction, the ability to epigenetically turn off inflammatory genes is a massive therapeutic advantage
