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As shown in an earlier publication, unconjugated bilirubin stimulates microglia primary cultures to respond by acquiring a phagocytic phenotype, which is transformed into an inflammatory response featuring secretion of the pro-inflammatory cytokines interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF)-, increased regulation of cyclooxygenase (COX)-2, and enhanced the activities of MMP- 9 and -2 (188)

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