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Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells

20 While Class I FINs have shown some promise as inducers of ferroptosis in cancer cells in vivo , the development of analogs with greater potency in vivo remains a high priority.14,17,21 Inhibiting GPX4 has recently been pinpointed as a means to selectively kill drug-resistance cancer cell sub-populations

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When selenium is reduced, some selenoproteins in the body quickly disappear (low grades), while others can continue to be synthesized even when selenium levels are reduced (high grades) (Banning et al., 2008b)