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That shift in timescale is not just a pharmacological footnote
Early preclinical data suggests it may influence neurovascular stability and axonal regeneration pathways, making it of interest in neural injury research [5]
We also think it is being discussed in ways that do patients more harm than good
Opioid-induced microglial activation has been shown to oppose opioid analgesia and enhance tolerance, whereas inhibition or absence of this activation attenuates tolerance development [221,222]
