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14 In the newborn period, GHD can be acquired due to trauma peri- or postnatally

The use of naturally existing adrenergic receptor ligands, such as the alkaloid ephedrine from the herb Ephedra , can be traced back to ancient Asia

Conversely, it was observed that excessive accumulation of mitochondria Ca 2+ led to mitochondrial rupture and a decline in mitochondrial function in Lysosomal storage-diseases (LSDs) (Cantarero et al., 2021), suggesting that mitochondrial biogenesis can be inhibited as a protective mechanism in cells and tissues when lysosomes are defective (Khalil et al., 2017), indicating that lysosomes and mitochondria are interdependent and coordinate across time and space barriers, to complete complex cell metabolism, signal transduction, and other functions to maintain the homeostasis of the whole cell (Qing-long, 2022)

Blockage of O-linked GlcNAcylation induces AMPK-dependent autophagy in bladder cancer cells