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Description
The toxicity of 5-azadC limits its clinical application, but combining it with histone deacetylase inhibitors like sodium butyrate has shown synergistic effects in FXS lymphoblastoid cell lines, leading to more effective restoration of FMR1 gene activity
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[DOI] [PubMed] [Google Scholar] 36.Steinke B, et al
RSV was shown to activate SIRT1 and improve endothelial function in obese mice via upregulation of PPAR expression/activity in PPAR mutant mice (Cheang et al., 2019)
