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Furthermore, identifying key proteins associated with the senescent phenotype may reveal novel therapeutic targets, enabling the development of rational drug combinations that enhance anti-tumour efficacy, lower required dosages, reduce systemic toxicity, and help overcome resistance mechanisms

Other concerns flagged included suspicions around the timeline between attaining ethical approval and actually commencing the study, the fact that the trial was not randomized considered by many to be the gold standard for clinical trials and the removal of four treated patients from the final dataset, three of whom were escalated to intensive care and one of whom died