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The search strategy, developed according to PRISMA, and Cochrane best practices, encompassed five major databases (PubMed/MEDLINE, Cochrane Library, Google Scholar, ClinicalTrials.gov, and ProQuest) alongside manual searches of key references, grey literature, and clinical trial registries to ensure comprehensive retrieval of both published and unpublished studies

This clinical trial showed that gradual escalation of the febuxostat dose reduces the risk of gout flares compared with full-dose febuxostat when starting urate-lowering therapy

Associations of atrophic gastritis and proton-pump inhibitor drug use with vitamin B 12 status, and the impact of fortified foods, in older adults

They make it water soluble and help you excrete it through urine