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Description
Lipids 2013, 167168, 2132

The FDA cited three concerns: potential immunogenicity (the peptide could trigger immune reactions), manufacturing impurity risks (synthetic peptides can contain truncated sequences and other contaminants), and a lack of human safety data sufficient to evaluate risk
Blomley MJ, et al

It has therefore been suggested that the decrease in estrogen at menopause may be important in the pathophysiology of development of OA
