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Its not uncommon in medicine to encounter situations where a treatment, especially one addressing a longstanding deficiency, might initially seem to exacerbate symptoms

While folic acid is the key preventive measure for neural tube defects, ensuring adequate B12 status is also important for overall maternal and foetal health

So this is the response from my doctor

[2] For more persistent or severe acne, your GP may prescribe oral antibiotics (such as lymecycline or doxycycline) for up to 12 weeks, alongside appropriate topical treatments
