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UK red flags warranting prompt medical review include sudden patchy hair loss, signs of scalp scarring or persistent inflammation, hair loss in children, and hair loss accompanied by systemic symptoms such as fatigue, weight change, or skin changes

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Van HMJ, Zhang Y, Thijssen V, Buijs N, Gao Y, Mateuszuk L, Fedak FA, Kij A, Campagna R, Sartini D (2021) Macrocyclic peptides as allosteric inhibitors of nicotinamide N -methyltransferase (NNMT)

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