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Similarly, ketamine has been shown to be effective in inducing long-lasting changes in synaptic plasticity in depression-like behaviors in several models, including chronic corticosterone (CORT) associated with repetitive restraint stress [30], anxiety disorders associated with post-traumatic stress disorder (PTSD) [31], chronic pain [32], and middle cerebral artery occlusion associated with chronic unanticipated mild stress [33]
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Research has also documented Semax-induced upregulation of nerve growth factor (NGF) mRNA in both rat hippocampus and in glial cell cultures suggesting that neurotrophin upregulation by Semax extends beyond the BDNF axis to encompass the broader neurotrophin family

NaBPC157 proves useful as an antiarrhythmic, antianginal and cardioprotective agent
