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The cell regulates ROS levels via numerous defense systems involving a variety of different antioxidant compounds (e.g

doi: 10.3322/caac.21660 2 MatsuiRInakiNTsujiT
Guttridge DC, Albanese C, Reuther JY, Pestell RG, Baldwin AS Jr

Notably, loss-of-function mutations in ABCG2 (e.g., Q141K) impair intestinal urate excretion, thereby significantly increasing the risk of gout (Kawaguchi et al., 2021
