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10.1104/pp.110.162123 Plant Physiol

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It is the task of the surgical pathologist to provide an accurate, specific, and sufficiently comprehensive diagnosis to enable the clinician to develop an optimal plan of treatment and, to the extent possible, estimate prognosis

Moreover, we lack insight into how these changes mediate such profoundly specific alterations to gene expression when they affect seemingly fundamental and cell-wide processes (i.e., Ac-CoA availability)
