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Description
Its mechanisms involve direct scavenging of free radicals, activation of the Nrf2 pathway to enhance cellular antioxidant defenses, and upregulation of SIRT3 to improve mitochondrial function and biogenesis [192]
Furthermore, melatonin and its metabolites protect lipids, proteins, and DNA against oxidative damage and nitrosative stress [2,3]
However, excessive intake can lead to adverse health effects, including selenium toxicity
doi:10.2147/COPD.S89849 18
