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Cell clusters of interest were further divided into subsets and subjected to normalization, scaling and PCA as described above

The impact of genetic variation on metabolism of heavy metals: Genetic predisposition

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Oxidative stress is a transient or long-term increase of the steady-state level of reactive oxygen species (ROS) leading to oxidative modifications of biomolecules and cell death via necrosis or apoptosis ( FIGURE 3 Under homeostatic conditions, transcription factor Nrf2 is synthesized but constantly subjected to proteasomal degradation mediated by Keap1 (Kelch like ECH associated protein 1)