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This approach, which often involves applying a fraction of the standard dose, is designed to investigate the cellular or physiological responses without provoking the full-blown effects of the drug
Similarly, resveratrol has an estimated intestinal absorption of 70% although its plasma bioavailability is less than 1%, due to extensive first-pass metabolism in the liver and intestinal wall, which converts the compound into water-soluble sulphates and glucuronides that are rapidly excreted through bile and urine [54, 55]
*J Physiol Paris.* 95(1-6):315-24
doi: 10.1152/ajpheart.00673.2009
