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Pancreatitis : Individuals with a history of pancreatitis should avoid semaglutide or use it cautiously

Many people begin to notice changes within a few weeks, with fuller benefits building over several months of consistent, supervised use

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As it wears down, bone-on-bone contact produces the pain, stiffness, and swelling that can reshape your daily life.[5] The standard treatments (NSAIDs, corticosteroid injections, eventually joint replacement) are focused almost entirely on managing symptoms