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Dig Dis Sci (2005) 50(5):91421.10.1007/s10620-005-2664-z 80 WeissGATroxlerHKlinkeGRoglerDBraeggerCHersbergerM

Melasma is influenced by various factors, including UV radiation, inflammation, and hormonal changes, all of which can generate free radicals and lead to oxidative damage in the skin

The negative consequences of the divide for how science is designed, produced and communicated and how action on the ground is implemented have been highlighted at all scales from international to local 4,5 and across various themes and sectors 6,7,8,9

Potential Drawbacks Peaks and troughs can still occur if injection intervals are too long