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Description
Methods Biochem

DSIP demonstrates remarkable stress-protective properties by modulating the hypothalamic-pituitary-adrenal axis, reducing ACTH and cortisol responses to both physical and psychological stress

However, pathologic conditions activate microglia to increase cytokine production, resulting in either a pro-inflammatory or anti-inflammatory phenotype, classically defined as M1 and M2, respectively, (Woodburn et al., 2021

and inflammatory and immune mechanisms that develop concurrently with the aforementioned processes
