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Relative telomere length assay Relative telomere length was determined using real-time quantitative PCR according to Cawthon et al.s protocol 51 , where the relative telomere to single copy gene (T/S) ratios was determined using a standard curve

REDEFINE 1 and REDEFINE 2 ran 68 weeks, with the first ~16 weeks dedicated to dose titration

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64 Nanomaterials can mimic pathogen-associated molecular patterns to activate pattern recognition receptors, such as Toll-like receptors (TLRs), on the surface of host cells