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(1) Both these findings on chronic and acute action of AOD 9604 suggested that while enhanced beta(3)-AR expression may have played a role in the chronic action of the compound, beta(3)-AR might not be the sole arbiter in this reaction

Conclusion: The 5-amino-1MQ peptide is turning our view of molecular biology in a new and surprising direction

J Med Chem 62:98379873
This pattern is not unique to tirzepatide but reflects the biology of obesity and metabolic adaptation
