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1,18,19,20,21 The above-mentioned therapeutic approaches have gained evident and encouraging responses in treating patients with advanced melanoma and some of them have also been approved in the adjuvant setting

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6.2.1.2 5-Fluorouracil resistance Metabolic plasticity of serine metabolism constitutes one of the critical metabolic pathways underlying 5-fluorouracil (5-FU) resistance in colorectal cancer

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