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169,170,171 The activation of LOX/LOXL stimulates signaling pathways involving protein kinase C and protein tyrosine kinase 2, further driving the activation of transcription factors associated with cancer cell proliferation and metastasis

Finally, GSH deficiency contributes to oxidative/nitrosative stress, a condition actually connected with the pathogenesis of many diseases, including cancer, diseases of aging, cystic fibrosis, infection and neurodegeneration

Penaeus monodon (Sivagnanavelmurugan et al., 2014), Marsupenaeus japonicus (Traifalgar et al., 2010), Pelteobagrus fulvidraco (Yang et al., 2014), Litopenaeus vannamei (Sinurat et al., 2016), Labeo rohita (Mir et al., 2017

This suggests that ox-mtDNA-mediated chronic low-grade inflammation directly promotes multi-organ functional decline (Jimnez-Loygorri et al., 2024)