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However, when oxidative stress becomes prolonged and cellular systems are no more able to counteract the oxidative-mediated insults, the amount of free GSH decreases leading to irreversible cell degeneration and death

UASVM Food Sci

Kyung, S

Native peptide drugs, however, are generally ineffective when given orally due to low oral bioavailability, which is as a result of the physical and biochemical barriers of the gastrointestinal tract (GIT), often forcing the use of invasive parental delivery methods that lead to low patient compliance [3,4]
