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Nanometer scale pores similar in size to the entrance of the ribosomal exit cavity are a common feature of large RNAs

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Figure 5 While immune complexes are known to be immunogenic, immune complex-mediated immunogenicity is typically driven by mechanisms that are lacking from the aglycosylated SEFL Fc domain of AMG 966, such as FcR binding ( in vitro and assessed binding to FcRIa, FcRIIa, and FcRIIIa compared to AMG 966 alone in a competitive AlphaLISA binding assay

[4] Bi-Amino Injection is contraindicated in patients with severe renal impairment, hepatic failure, baseline hyperkaliemia, or uncompensated metabolic acidosis