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GSTs were first recognized as enzymes inactivating xenobiotics, in particular electrophilic mutagens and carcinogens, leading to their excretion as mercapturic acids (Mannervik, 1985

Notably, Gln deprivation significantly reduced the expression of CCNB1, CDK1 and p-CDK1 in HCC and PCa cells (Fig

Furthermore, A is able to promote the hyperphosphorlyation of Tau in both the cytosolic and synaptic compartments, which has been suggested as a potential explanation of the prion-like seeding hypothesis of Tau transmission inter-neuronally, accounting for the phosphorylated Tau detected in the CSF of AD patients (Wu et al., 2018