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Instead, the impact of this potential source of errors could only be evaluated by using more complicated explicit models in combination with our above presented method for estimating the proton solvation energy

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A retrospective study looking at concomitant use of proton pump inhibitors (PPIs) alongside metformin in 614 people with type 2 diabetes in the US found a significant reduction in B12 levels of 34% in patients taking both medications, compared to controls taking either drug alone (Long et al, 2012)