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Oncology and Therapy
24 Compared with solvent treatment, populations of control (EV) RNAi animals treated with metabolite have significantly greater fragmentation characterized by circularly shaped mitochondria, which is potentially indicative of increased mitophagic activity due to decreased mitochondrial fission and more rapid turnover of mitochondria (Figures 5a and b)
More importantly, chronic administration of these direct blockers leads to up-regulation of DAT expression [12, 13], which possibly underlie the increased risk for subsequent substance use disorders [14, 15]
Various biomarkers are not all equivalent and have differential value for disease diagnosis and drug development
