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* Correspondence: Gen Ohtsuki, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Contrary to our initial expectations, the cystine/glutamate transporter was expressed in very limited cell populations within TLS

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Its core pathogenesis involves intestinal mucosal barrier dysfunction, gut microbiota dysbiosis, and aberrant immune responses